When connected to the VPN using the 2-Step Secured - allthruucsd group, all of the traffic to and from your home or remote computer has malware filtered exactly as any on-campus computer does.
As such you should feel free to rely on the VPN anytime you are working remotely. In response to the surge in remote workers, IT Services has significantly upgraded the capacity and performance of the VPN service.
VPN Use During Temporary Remote Work Directives Spring 2020